Slides and Transcript
Slide 2 of 30
É um agonista parcial mu-opioide e, em menor grau, um antagonista kappa-opioide. A buprenorfina se liga muito fortemente ao receptor mu-opioide, portanto, qualquer opioide será deslocado. Além disso, as formulações originais eram sublinguais devido à baixa biodisponibilidade oral.
References:
- Substance Abuse and Mental Health Services Administration. (2021). Practical tools for prescribing and promoting buprenorphine in primary care settings (SAMHSA Publication No. PEP21-06-01-002). National Mental Health and Substance Use Policy Laboratory.
- Center for Substance Abuse Treatment. (2004). Clinical guidelines for the use of buprenorphine in the treatment of opioid addiction. Substance Abuse and Mental Health Services Administration (US).
Slide 3 of 30
Além disso, a buprenorfina pode satisfazer os receptores opioides, de modo que a abstinência e os desejos são reduzidos e os opioides ilícitos deixam de ser prazerosos. Em geral, a buprenorfina é combinada com a naloxona para reduzir o uso indevido, como, por exemplo, a injeção do medicamento. Hoje, vamos usar principalmente a buprenorfina/naloxona sublingual combinada para manter a discussão simples.
References:
- Substance Abuse and Mental Health Services Administration. (2021). Practical tools for prescribing and promoting buprenorphine in primary care settings (SAMHSA Publication No. PEP21-06-01-002). National Mental Health and Substance Use Policy Laboratory.
- Center for Substance Abuse Treatment. (2004). Clinical guidelines for the use of buprenorphine in the treatment of opioid addiction. Substance Abuse and Mental Health Services Administration (US).
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